Endocrine Abstracts

Introduction: Obesity is a chronic disease which has become a global epidemic. Approximately 7% of deaths per year is associated with obesity, especially because of its complications such as cardiovascular diseases, type 2 diabetes or cancer. Lifestyle interventions are the first line of management but additional pharmacotherapy or bariatric surgery should be considered in more severe cases.Case report: A 40-year-old woman was referred to Endocrinology O...

Introduction: The thyroglossal duct develops during thyroid gland formation and usually involutes at 7–10 weeks gestation. Its residue can lead to formation of cysts as well as to develop neoplasms within the mass.Case report: A 40-year-old woman was admitted to Department of Otolaryngology because of an enlarging midline neck mass for the last few months, without other worrisome symptoms. A neck ultrasound and CT scan showed a cystic lesion with s...

IntroductionCoronavirus disease (COVID-19) caused by SARS-CoV-2 infection, resulted in serious respiratory and other systemic complications, has spread worldwide since December 2019. In patients with the infection, many organ systems can be involved with potentially fatal results due to robust and disorganized systematic immune activation.The state of the artSince the outbreak of the SARS-CoV-2 pandemic, many...

IntroductionThe novel COVID-19 has been rapidly expanding and causing many deaths all over the world, since December 2019. The health condition and the coexistence of other diseases may affect the severity of SARS-CoV-2 infection.The state of the artPCOS is a common endocrine and metabolic disorder, afflicting females of reproductive age, with an incidence up to 10%. It is a heterogeneous clinical syndrome, c...

Introduction: Turner syndrome (TS) is the most common chromosomal abnormality in women. It occurs in 1/2500 to 1/3000 live-born females and results from a total or partial absence of the X chromosome. The clinical manifestations are diverse and TS is accompanied by multiple medical problems.Methods: We analysed retrospectively six cases of women with TS aged 20–66 years, treated at Endocrinology Department between 2003 and 2014, to describe endocrin...

Introduction: Autoimmune polyglandular syndromes (APS) are a heterogeneous group of disorders characterised by autoimmune activity against endocrine and non-endocrine organs. APS type depends on the combination of the diseases (APS1, APS2, and APS3).Methods: The study was conducted in 89 patients (70F and 19M) with APS aged mean 50.00±14.80 years, treated at Endocrinology Department between 2003 and 2015. We analysed clinical manifestations, results...

Introduction: Von Hippel–Lindau (VHL) disease is a rare autosomal dominant syndrome (1/36 000 live births) with highly penetrance that predisposes to the development of benign and malignant, highly vascularised tumours in many organs.Case reports: Two women with VHL, without family history of VHL, were admitted to Department of Endocrinology for checkups. The diagnosis was made based on genetic tests.Patient A: A 53-year-old w...

Introduction: About 1% of primary hyperparathyroidism is due to parathyroid carcinoma. The affected gland is often indistinguishable from atypical adenoma. The proper diagnosis is usually made when the disease recurs or metastases are present and then is connected with poor prognosis.Case report: A 49-year-old man, after resection of parathyroid adenoma (postoperatively with normalization PTH concentrations and hungry bone syndrome), with limbs’ fra...

Introduction: The enlarged pituitary gland of pregnancy is susceptible to any compromise to its blood supply. Sheehan’s syndrome (SS) occurs as a result of post-partum pituitary infarction or haemorrhage and usually leads to hypopituitarism. It can be fatal but clinical manifestations may change from one patient to another and symptoms may not occur for many years.Methods: We analysed retrospectively five cases of women with SS aged 26&#150...

Introduction: Neurofibromatosis type 1 (NF1; von Recklinghausen’s disease) is an autosomal disorder with the prevalence 1 in 3,000 births. It is caused by mutation of the tumour-suppressor gene encoding neurofibromin. NF1 may affect various organs and patients are at increased risk of developing many neoplasms.Material and methods: We analysed seven cases of patients with NF1 (four females and three males) aged 19–52 who were treated at Endocri...